Aeolian dust input is an important source of iron (Fe) for phytoplankton growth in some oceanic regions. However, the efficiency of Fe uptake by phytoplankton may partly depend on Fe properties, in particular Fe solubility and speciation, as soluble Fe is believed to be more readily used by marine organisms. Many processes in the atmosphere, such as interactions between dust particles and pollution derived substances, may alter dust properties and then Fe bioavailability. Here we present some of our effects on taking integrated approaches to quantify Fe solubility and its input to the ocean through in-situ measurements, laboratory experiments and model simulations. We conducted field measurements to investigate the interactions of different aerosol species focusing on their size-distributions using a MOUDI impactor. We also targeted on Fe solubility using UV spectrometry based on samples collected on the New Jersey coast. We used an atmospheric transport model to simulate and evaluate the heterogeneous processes and magnitude of soluble Fe deposition to the ocean. Preliminary results suggest that heterogeneous chemical processes play an important role on Fe solubility and the magnitude of soluble Fe input to the ocean may be affected by anthropogenic air pollution.